K⁺ Channel α Mouse, Unlabeled, Clone: 32, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 611248

Product Code. 15875849

Description

Cellular excitability is modulated by the precise function of voltage-sensitive ion channels. Large conductance potassium channels (Maxi-K) are unique in that they are sensitive to transmembrane potential and intracellular Ca²⁺; concentrations. These channels, important for neuronal firing and vascular tone, share many features with voltage-dependent Na⁺, Ca²⁺;, and K⁺ channels. Among these are the S4 region, a motif with a repeated triple sequence of one positively charged amino acid and two hydrophobic amino acids. This region is thought to be the voltage sensor. Maxi-K is subject to complex metabolic control control that also involves G proteins and phosphorylation/dephosphorylation reactions. This type of K⁺ channel is composed of two subunits, the pore-forming α subunit (hslo) and the regulatory β subunit. The α subunit is subject to direct phosphorylation by cyclic GMP-dependent protein kinase (PKG) and dephosphorylation by protein phosphatase 2A. The fact that the α subunit of Maxi-K channels is a substrate of PKG supports the idea that these channels perform an important function in the cellular response to potent vasodilators, such as nitrocompounds and atrial natiuretic peptide.

Host Species: Mouse
Clone: 32
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Human K⁺ Channel α Subunit aa. 995-1113
Formula Weight [Chemical]: 125kDa

Immunofluorescence, Western Blotting

Specifications

• Antigen: K⁺ Channel α
• Classification: Monoclonal
• Concentration: 250μg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Human K⁺ Channel α Subunit aa. 995-1113
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Human, Mouse, Rat
• Isotype: IgG1

• Applications: Western Blot
• Clone: 32
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.