JNK1/JNK2 Mouse anti-Human, Unlabeled, Clone: G151-666, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 554285

Product Code. 15897638

Description

C-Jun NH2-terminal kinase (JNK) binds to the c-Jun terminal transactivation domain and phosphorylates it on Ser-63 and Ser-73. Phosphorylation enhances the transcriptional activity of c-Jun. The Ser-Pro-acidic sequence targeted by JNK kinase activity establishes it as a prolinedirected kinase related to the MAP kinases and cyclin/dependent kinases. JNK may act as a tumor promoter in response to UV-irradiation since its activity is potently stimulated by radiation. This has relevance to observations that c-Jun transcriptional activity is upregulated by UV irradiation. In addition to UV irradiation, JNK is also activated by some other forms of cellular stress, including heatshock. Both the JNK1 (46kDa) and JNK2 (54kDa) isozymes appear equally capable of binding to the c-Jun terminal transactivation domain following induction by UV irradiation or heatshock. G151-666 recognizes both the JNK1 and JNK2 isozymes of JNK1. A bacterially expressed fusion protein of human JNK1 was used as immunogen.

Host Species: Mouse
Clone: G151-666
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Human JNK1 Fusion Protein

Immunoprecipitation, Western Blotting

Specifications

• Antigen: JNK1/JNK2
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Human JNK1 Fusion Protein
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgG2a

• Applications: Western Blot
• Clone: G151-666
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.