IRF3 Mouse anti-Human, Clone: 17C2, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen 392700

Product Code. 10456793

Description

Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells. Following viral infection, IRF3 can be activated by Ikappa-B kinase-iota and TANK-binding kinase 1 (TBK1), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA. IRF3 exists as at least two distinct isoforms.

Specifications

• Antigen: IRF3
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Gene: IRF3
• Gene Alias: IRF3, Interferon regulatory factor 3
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 3661
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Immunofluorescence, Western Blot
• Clone: 17C2
• Conjugate: Unconjugated
• Gene Accession No.: Q14653
• Gene Symbols: IRF3
• Immunogen: Recombit protein derived from the C-terminal region of the human IRF3 (interferon regulatory factor 3) protein
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a