IREB2 Polyclonal Antibody, Invitrogen™

Goat Polyclonal Antibody

Brand:  Invitrogen PA519158

Product Code. 11367133

Description

This antibody is predicted to react with mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).

Specifications

• Antigen: IREB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IREB2
• Gene Alias: ACO3; D9Ertd85e; FLJ23381; im:7153062; Ireb2; IRE-BP 2; IREBP2; Iron regulatory protein 2; iron responsive element binding protein 2; iron-regulatory protein 2; iron-responsive element binding protein 2; iron-responsive element-binding protein 2; Iron-responsive element-binding protein 2-like protein; IRP2; IRP2AD
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 3658, 64602, 64831
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P48200, Q62751, Q811J3
• Gene Symbols: IREB2
• Immunogen: Synthetic peptide sequence (SIHYEGSEYKLSHGS) corresponding to the internal amino acids of IREB2
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG