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IL-17A Mouse anti-Human, PE, Clone: SCPL1362, BD
Mouse Monoclonal Antibody
£144.63 - £350.28
Specifications
| Antigen | IL-17A |
|---|---|
| Clone | SCPL1362 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Conjugate | PE |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15840199
|
BD Biosciences
560438 |
25 Tests |
 £151.00 £144.63 / Each Save £6.37 4% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
|
15820199
|
BD Biosciences
560436 |
100 Tests |
£362.00 £350.28 / Each Save £11.72 3% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
Human IL-17A, also known as IL-17, is a proinflammatory cytokine that is encoded by the IL17A gene in chromosome 6. IL-17A is produced as a disulfide-linked homodimer comprised of two mature 136-amino acid polypeptides. It is a member of the IL-17 family of structurally related cytokines, designated IL-17A through IL-17F. Activated memory T cells, especially Th17 cells (specialized IL-17A-producing CD4+ T cells distinct from Th1 and Th2 cells) produce IL-17 and provide protective immunity against pathogens. Activated CD8+ T cells, γδT cells, NK cells and neutrophils can also be activated to produce IL-17A. IL-17A binds to and exerts its biological activity through IL-17 receptors (IL-17R) that are expressed by a variety of target cells including fibroblasts, epithelial and endothelial cells, monocytes/macrophages and mast cells. The ubiquitous IL-17R expression pattern may explain the broad tissue responsiveness to IL-17. IL-17 induces stromal cells to secrete cytokines and chemokines involved in inflammatory and hematopoietic processes. For example, IL-17 induces fibroblasts to produce IL-6, IL-8, G-CSF and express increased surface ICAM-1. The SCPL1362 antibody reacts with human IL-17A.
Host Species: Mouse
Clone: SCPL1362
Isotype: IgG1 κ
Species Reactivity: Human
Intracellular Staining
Specifications
| IL-17A | |
| Flow Cytometry | |
| PE | |
| RUO | |
| Human | |
| IgG1 κ | |
| Affinity Purified | |
| IL-17; IL-17A; CTLA8; Cytotoxic T-lymphocyte-associated serine esterase 8 |
| SCPL1362 | |
| Monoclonal | |
| Mouse | |
| Immunology | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
For Research Use Only.
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