IL-1β Mouse anti-Human, Unlabeled, Clone: AS10, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 550007

Product Code. 15816168

Description

The AS10 antibody reacts with human interleukin-1β (IL-1β) which is also known as endogenous pyrogen (EP), leukocyte endogenous mediator (LEM), mononuclear cell factor (MCF) and lymphocyte-activating factor (LAF). IL-1β is a proinflammatory cytokine that is synthesized as a precursor of 31kDa and is converted intracellularly to the mature 17.5kDa form, after cleavage by the IL-1β-converting enzyme (ICE). In healthy individuals, IL-1β is secreted non-constitutively by blood monocytes, tissue macrophages and dendritic cells. IL-1β is also constitutively expressed in the human hypothalamus. Many malignant tumors express IL-1β as part of their neoplastic nature. The immunogen used to generate the AS10 hybridoma was recombinant human E. Coli-expressed recombinant IL-1β. The AS10 antibody does not cross react with mouse IL-1β. This is a neutralizing antibody.

Specifications

• Antigen: IL-1β
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Recombinant human IL-1β
• Quantity: 0.25 mg
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Immunocytochemistry
• Clone: AS10
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.