GluR6/GluR7 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA532427

Product Code. 13446947

Description

This antibody is predicted to react with bovine, chicken, canine, amphibian, mouse, rabbit and rat based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is brain tissue.

Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors, which when activated can activate phopholipases or adenylylcyclase, depending on the neuron.

Specifications

• Antigen: GluR6/GluR7
• Classification: Polyclonal
• Gene: GRIK3
• Gene Alias: GRIK2, GRIK3, EAA4, GLR6, MRT6, GLUK6, GLUR6, GluK2, Glutamate Receptor 6/7, Glutamate Receptor 6, Glutamate Receptor 7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2898, 2899, 54257
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: P42260, Q13002, Q13003
• Gene Symbols: GRIK2, GRIK3
• Immunogen: Synthetic peptide from C-terminus of human GluR6/7.
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG