GluR δ2 Mouse, Unlabeled, Clone: 48, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 611006

Product Code. 15835759

Description

Glutamate is a major excitatory neurotransmitter of the CNS. The diversity of glutamate is exemplified by two distinct groups of receptors: ionotropic and metabotropic. Ionotroic receptors are ligand-gated cation channels. They can be subdivided into two classes: NMDA and AMPA/kainate receptors. GluR δ2 exhibits only 25% amino acid identity to either ionotropic receptor type. It presents selective and abundant exression in cerebellar Purkinje cells. It is targeted to a subset of Purkinje cell spines and is coexpressed with ionotropic receptors. GluR δ2 is involved in motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression (LTD). The latter is a decrease in the efficacy of the synaptic transmission between parallel fibers and Purkinje neurons and is a cellular basis of motor learning. In fact, mGluR δ2-deficient mice lack LTD. Additionally, an amino acid substitution in transmembrane III of δ2 is responsible for the neurodegeneration seen in Lurcher mice. This substitution is a gain of function mutation that results in disruption of Purkinje membrane potential. Thus, GluR δ2 is an important regulatory component of the Purkinje GluR channel.

Immunofluorescence, Western Blotting

Specifications

• Antigen: GluR δ2
• Classification: Monoclonal
• Concentration: 250μg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Mouse GluR δ2 aa. 665-786
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Mouse, Rabbit, Rat
• Isotype: IgG1

• Applications: Western Blot
• Clone: 48
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.