GNB3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen OSG00021W

Product Code. 10577610

Description

Glycerol (1:1) may be added for additional stability.

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.

Specifications

• Antigen: GNB3
• Classification: Polyclonal
• Gene: GNB3
• Gene Alias: Transducin beta chain 3, GNB3, Guanine nucleotide binding protein subunit beta-3
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: P16520, Q61011, P52287
• Gene Symbols: GNB3
• Immunogen: A synthetic peptide from aa region 2-50 of human GNB3 conjugated to an immunogenic carrier protein was used as the antigen
• Regulatory Status: RUO
• Gene ID (Entrez): 14695, 2784, 60449
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized