GPRC6A Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA132735

Product Code. 11522562

Description

PA1-32735 detects GPCR GPRC6A from human samples.

GPRC6A is an Orphan-U GPCR with an unknown ligand. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "e;turn-off"e; activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: GPRC6A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPRC6A
• Gene Alias: bA86F4.3; G protein-coupled receptor class C group 6 member A; G protein-coupled receptor, class C, group 6, member A; G protein-coupled receptor, family C, group 6, member A; GPCR; Gprc6a; G-protein coupled receptor family C group 6 member A; G-protein coupled receptor GPCR33; hGPCR33; hGPRC6A; predicted with SOSUI analysis; seven transmembrane helix receptor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 222545
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q5T6X5
• Gene Symbols: GPRC6A
• Immunogen: Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GPRC6A
• Quantity: 25 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG