FANCD2 Polyclonal Antibody, Invitrogen™
FANCD2 Antibody, PA1-16548, from Invitrogen™. Species Reactivity: Human, Mouse, Non-human primate; Applications: FACS, ICC, IF, IHC, IHC (Paraffin), WB.
Brand: Invitrogen PA116548
Code : LD
Additional Details : Weight : 0.01000kg
DescriptionFanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Non-human primate
Immunogen: Human FANCD2 fusion protein (N-terminal fragment).
Formulation: 50μL purified antibody (1mg/mL) in PBS and 0.05% sodium azide
Synonyms: FA4, FACD, FAD, FAD2, FANCD, FANCONI ANEMIA COMPLEMENTATION GROUP D, FANCONI PANCYTOPENIA TYPE 4
Uniprot Accession: Q80V62, Q9BXW9
Entrez GeneID: 211651, 2177
Gene Symbol: FANCD2
In Western blot, this antibody should recognize a band at ∽166 kDa (post-translationally modified form). Additional bands may be seen at lower molecular weights. In immunofluorescence, this has been tested in human MMC and IR-treated MEF cells.Suggested positive control: Hela whole cell extract.
Test: IHC, Dilution: 1:200, Species: Hu, Reference: Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure. (2014) BMC Cancer, Vol: 14, , 246, Balacescu O,Balacescu L,Tudoran O,Todor N,Rus M,Buiga R,Susman S,Fetica B,Pop L,Maja L,Visan S,Ordeanu C,Berindan-Neagoe I,Nagy V; Pubmed ID: 24708616
|FA4, FACD, FAD, FAD2, FANCD, FANCONI ANEMIA COMPLEMENTATION GROUP D, FANCONI PANCYTOPENIA TYPE 4|
|Avoid Freeze/Thaw Cycles|
|50μL purified antibody (1mg/mL) in PBS and 0.05% sodium azide|
|Human FANCD2 fusion protein (N-terminal fragment).|