FANCD2 Polyclonal Antibody, Invitrogen™

FANCD2 Antibody, PA1-16548, from Invitrogen™. Species Reactivity: Human, Mouse, Non-human primate; Applications: FACS, ICC, IF, IHC, IHC (Paraffin), WB.

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-16548

FANCD2

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11555313

Quantity Price
1 £ 303.0 / 50µL
Estimated Shipment date
from Supplier 21-12-2016
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Description and Specification

Specification

Antigen FANCD2
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry
Applications Immunohistochemistry (Paraffin)
Applications Western Blot
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Non-human primate
Format Purified
Formulation 50μL purified antibody (1mg/mL) in PBS and 0.05% sodium azide
Gene Accession No. Q80V62, Q9BXW9
Gene Alias FA4, FACD, FAD, FAD2, FANCD, FANCONI ANEMIA COMPLEMENTATION GROUP D, FANCONI PANCYTOPENIA TYPE 4
Gene Symbols FANCD2
Host Species Rabbit
Immunogen Human FANCD2 fusion protein (N-terminal fragment).
Isotype IgG
Quantity 50μL
Species Reactivity Human, Mouse, Non-human primate
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 211651, 2177

Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Non-human primate
Isotype: IgG
Immunogen: Human FANCD2 fusion protein (N-terminal fragment).
Formulation: 50μL purified antibody (1mg/mL) in PBS and 0.05% sodium azide
Synonyms: FA4, FACD, FAD, FAD2, FANCD, FANCONI ANEMIA COMPLEMENTATION GROUP D, FANCONI PANCYTOPENIA TYPE 4
Uniprot Accession: Q80V62, Q9BXW9
Entrez GeneID: 211651, 2177
Gene Symbol: FANCD2
In Western blot, this antibody should recognize a band at ∽166 kDa (post-translationally modified form). Additional bands may be seen at lower molecular weights. In immunofluorescence, this has been tested in human MMC and IR-treated MEF cells.Suggested positive control: Hela whole cell extract.
References:
Test: IHC, Dilution: 1:200, Species: Hu, Reference: Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure. (2014) BMC Cancer, Vol: 14, , 246, Balacescu O,Balacescu L,Tudoran O,Todor N,Rus M,Buiga R,Susman S,Fetica B,Pop L,Maja L,Visan S,Ordeanu C,Berindan-Neagoe I,Nagy V; Pubmed ID: 24708616