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FAK (pY397) (Focal Adhesion Kinase (pY397)) Mouse anti-Human, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

£248.00 - £462.00

Specifications

Antigen FAK (pY397) (Focal Adhesion Kinase (pY397))
Clone 18
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15846029
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BD Biosciences
611806
50 μg
£248.00
1 set
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Estimated Shipment: 02-05-2024
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15856029
View Documents Promotion Details
BD Biosciences
611807
150 μg
£462.00
1 set
View alternative products
Save Up to 
»
Estimated Shipment: 02-05-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
Description

Description

Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. This cellular localization is directed by a 125 amino acid sequence at the C-terminus called “Focal Adhesion Targeting” sequence (FAT). The binding of extracellular matrix ligands to integrins triggers autophosphorylation at Tyr-397, and activation of FAK through phosphorylation of Tyr residues (Tyr-576 and Tyr-577) in the kinase domain activation loop. For example, cell adhesion to a fibronectin substratum involves concurrent activation of Src and phosphorylation of the FAK activation loop. In addition, phosphorylation of other Tyr residues (Tyr-925 and Tyr-861) creates binding sites for SH2 domains of intracellular signaling molecules such as Src, PI3 kinase, and Grb2. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions is important for FAK activation level and for FAK interaction with a variety of substrates localized to sites of cell adhesion. Thus, FAK activity is regulated by a complex set of phosphorylation sites, and this phospho-regulation could be important for cell motility, cell growth, cytoskeletal organization and adhesion-dependent cell survival.

Host Species: Mouse
Clone: 18
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human FAK (pY397)

Bioimaging, Immunofluorescence, Western Blotting

Specifications

Specifications

FAK (pY397) (Focal Adhesion Kinase (pY397))
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
Focal Adhesion Kinase (pY397)
18
Western Blot
Unconjugated
RUO
Human
Human FAK (pY397)
Primary
Store undiluted at -20°C.
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