Invitrogen™ Ephrin A5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA545700

Product Code. 15536902

Description

Peptide sequence: FDGYSACDHT SKGFKRWECN RPHSPNGPLK FSEKFQLFTP FSLGFEFRPG Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%.

Ephrin A5 is a cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

Specifications

• Antigen: Ephrin A5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EFNA5
• Gene Alias: AF1; AL-1; AV158822; EFL5; EFL-5; EFNA5; EPH-related receptor tyrosine kinase ligand 7; ephrin A5; Ephrin-A5; Epl7; EPLG7; GLC1M; LERK7; LERK-7; RAGS
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13640, 1946
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: O08543, P52803
• Gene Symbols: EFNA5
• Immunogen: Synthetic peptide directed towards the middle region of human EFNA5.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG