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DSIF Mouse, Unlabeled, Clone: 17, BD
Mouse Monoclonal Antibody
£237.00 - £428.00
Specifications
| Antigen | DSIF |
|---|---|
| Clone | 17 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15855799
|
BD Biosciences
611107 |
150 μg |
£428.00
1 set |
Estimated Shipment: 03-06-2024 Log in to see stock. |
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|
15845799
|
BD Biosciences
611106 |
50 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
In living systems, the relative amounts of any protein are controlled at many levels. For example, amounts are affected by protein degradation, regulation of the translational rates of polypeptide synthesis (translational regulation), and control of the rates of mRNA synthesis (transcriptional regulation). Transcriptional regulation involves modulation of the rate-limiting enzyme RNA polymerase. DSIF (DRB sensitivity-inducing factor) is a heterodimeric transcription elongation protein. It is composed of a large subunit of 160kDa and a small subunit of 14kDa. These large and the small subunits are homologs of the yeast gene products Stp5 and Stp4, respectively. Spt4 and 5 are transcription factors which are critically important for the activity of RNA polymerase. In conjunction with DRB, DSIF attenuates RNA polymerase II elongation steps. However, in limiting amounts of ribonucleotides, DSIF, by itself, stimulates the elongation rate of RNA polymerase II. Thus, the identification of a human regulator for transcriptional elongation will greatly enhance our understanding of this critical step in mammalian gene expression.
Host Species: Mouse
Clone: 17
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human DSIF aa. 866-985
Formula Weight [Chemical]: 160kDa
Immunofluorescence, Western Blotting
Specifications
| DSIF | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 17 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Human, Mouse, Rat | |
| Human DSIF aa. 866-985 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.