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DNA Polymerase beta Monoclonal Antibody, Clone: 61, Invitrogen™

DNA Polymerase beta Antibody (61), MA5-12086, from Invitrogen™. Species Reactivity: Human; Applications: Western Blot.

Brand:  Invitrogen MA512086

UNSPSC : 12352203

Code : LE

Additional Details : Weight : 0.01000kg

Product Code. 11334573

  • £314.00 / 500┬ÁL


Estimated Shipment
08-09-2017
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Description

Description

DNA polymerase beta comprises an amino-terminal 8-kDa domain and a carboxy-terminal 31-kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.
Host Species: Mouse
Cross Reactivity: Human
Isotype: IgG2a
Clone: 61
Immunogen: DNA polymerase beta protein
Formulation: 500μL purified antibody (0.2mg/mL) in PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Synonyms: DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit
Uniprot Accession: P06746
Entrez GeneID: 5423
Gene Symbol: POLB
MA5-12086 targets DNA Polymerase beta in WB applications and shows reactivity with Human samples. The MA5-12086 immunogen is dNA polymerase beta protein.
References:
Test: WB, Dilution: 1:1000, Species: Hu, Reference: HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. (2014) Nat Commun, Vol: 5, , 5513, Fang Q,Inanc B,Schamus S,Wang XH,Wei L,Brown AR,Svilar D,Sugrue KF,Goellner EM,Zeng X,Yates NA,Lan L,Vens C,Sobol RW; Pubmed ID: 25423885
Specifications

Specifications

DNA Polymerase beta
61
500μL purified antibody (0.2mg/mL) in PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Purified
POLB
DNA polymerase beta protein
500μL
Store at 4° C
Monoclonal
Human
Western Blot
Unlabeled
P06746
DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit
Murine
IgG2a
RUO
Primary
5423