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POLB Monoclonal Antibody (61), Invitrogen™

Product Code. 11334573
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Quantity:
500 μL
Unit Size:
500µL
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Product Code. Quantity unitSize
11334573 500 μL 500µL
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Product Code. 11334573 Supplier Invitrogen Supplier No. MA512086

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Description

Mouse Monoclonal Antibody

MA5-12086 targets DNA Polymerase beta in WB applications and shows reactivity with Human samples. The MA5-12086 immunogen is dNA polymerase beta protein.

DNA polymerase beta comprises an amino-terminal 8- kDa domain and a carboxy-terminal 31- kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POLB
Applications Western Blot
Classification Monoclonal
Clone 61
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene POLB
Gene Accession No. P06746, P06766, Q8K409
Gene Alias A430088C08Rik; DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DNA-directed DNA polymerase beta; hypothetical protein LOC614688; LOW QUALITY PROTEIN: DNA polymerase beta; MGC125976; POL B; Pol beta; POLB; polb.S; polymerase (DNA directed), beta; polymerase (DNA directed), beta S homeolog; polymerase (DNA) beta; polymerase B; polymerase-beta; wu:fa97a05; XELAEV_18020165mg; zgc:109924
Gene Symbols POLB
Host Species Mouse
Immunogen DNA polymerase beta protein
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18970, 29240, 5423
Target Species Human, Mouse, Rat
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a
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