Disialoganglioside GD2 Mouse anti-Human, Unlabeled, Clone: 14.G2A, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 554272

Product Code. 15837638

Description

Gangliosides are sialic-acid bearing glycolipids that are expressed on the surface of all mammalian cells, and are likely involved in mediating cell-substratum interactions. They are important target antigens for antibody dependent cellular cytotoxicity (ADCC) of human melanoma and neuroblastoma cells. Human melanoma cells produce gangliosides, designated as GD2 and GD3 which are deposited in the subtratum-attached material, and may play a significant role in the melanoma metastatic phenotype. Clone 14.G2a specifically reacts with human and mouse GD2 ganglioside. LAN-1 human neuroblastoma cells were used as immunogen. Clone 14.G2a is an isotype switch variant selected from the parental IgG3-producing hybridoma 14.18 and has identical reactivity as the parental antibody. Clone 14.G2a is routinely tested by flow cytometry using M21 human melanoma cells.

Host Species: Mouse
Clone: 14.G2a
Isotype: IgG2a
Species Reactivity: Human
Immunogen: LAN-1 human neuroblastoma cells

Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen)

Specifications

• Antigen: Disialoganglioside GD2
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: GD2
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: 14.G2A
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: LAN-1 human neuroblastoma cells
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human, Mouse
• Isotype: IgG2a

For Research Use Only.