DCIR Mouse anti-Human, Alexa Fluor 647, Clone: I3-612, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 558220

Product Code. 15859248

Description

The I3-612 antibody reacts with DCIR, or dendritic cell immunoreceptor, a newly identified member of the calcium-dependent (C-type) lectin family. DCIR is a type II membrane glycoprotein with a single carbohydrate recognition domain (CRD). Its cytoplasmic tail contains a consensus immunoreceptor tyrosine-based inhibitory motif (ITIM). It is expressed on monocytes, macrophages, B-lymphocytes, granulocytes, but not on NK or T cells. DCIR is strongly expressed on dendritic cells derived from peripheral blood monocytes cultured in presence of GM-CSF and IL-4. Down-regulation is observed on these with further maturation using TNF-α or LPS. Reports describe the detection of two distinct inhibitory signals depending on its ITIM tyrosine residue.

Host Species: Mouse
Clone: I3-612
Isotype: IgG1, κ
Cross Reactivity: Human

Flow Cytometry

Specifications

• Antigen: DCIR
• Classification: Monoclonal
• Conjugate: Alexa Fluor 647
• Host Species: Mouse
• Quantity: 100 Tests
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: I3-612
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.