TYROBP Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA528803

Product Code. 13402927

Description

PA5-28803 targets DAP12 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-28803 immunogen is synthetic peptide corresponding to a region within amino acids 50 and 113 of Human DAP12. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined.

Specifications

• Antigen: TYROBP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: O43914
• Gene Symbols: TYROBP
• Immunogen: Synthetic peptide corresponding to a region within amino acids 50 and 113 of Human DAP12
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.65 mg/mL
• Gene: TYROBP
• Gene Alias: DAP12, KARAP, PLOSL, DNAX-activation protein 12, KAR-associated protein, TYRO protein tyrosine kinase-binding protein, killer activating receptor associated protein, killer-activating receptor-associated protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7305
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid