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Cyclin A Mouse anti-Human, Unlabeled, Clone: 25, BD

Product Code. 12820510
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150 μg
50 μg
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12820510 50 μg Each
15835859 150 μg 1 set
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Product Code. 12820510 Supplier BD Biosciences Supplier No. 611268

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Description

Mouse Monoclonal Antibody

Progression of the mammalian cell cycle is regulated by phosphorylation of many key proteins. Several classes of cyclins (A-E) act as regulatory subunits for cyclin-dependent kinases (cdks). These cyclin-cdk holoenzymes are essential for proper control of cell cycle progression. They phosphorylate and regulate a variety of substrates whose activity is required for cell cycle transitions. The temporal expression of cyclins is tightly regulated throughout the cell cycle by synthesis and degradation. Such regulation plays a critical role in controlling the enzymatic activity of the cdks. Cyclin A, one of the mitotic cyclins, activates Cdk2 near the start of S phase and is necessary for the initiation of DNA replication. In mammalian somatic cells, Cyclin A is required during S phase and passage through G2. The D and E type cyclins regulate passage through G1, while Cyclin B is a critical regulator of mitosis. It has been shown in a number of species that mutation or disruption of normal Cyclin A expression causes cells to arrest at G2. Cyclin A binds both the cdc2 (Cdk1) and Cdk2 kinases and may also have a role in mitotic dependence on S phase completion.

Host Species: Mouse
Clone: 25
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Cyclin A aa. 26-144
Formula Weight [Chemical]: 60kDa

Bioimaging, Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Cyclin A
Applications Western Blot
Classification Monoclonal
Clone 25
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Cyclin A aa. 26-144
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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