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  6. CXCR5 Rat anti-Human, BB515, Clone: RF8B2, BD

CXCR5 Rat anti-Human, BB515, Clone: RF8B2, BD

Product Code. 15863759
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15863759 100 Tests Each
15873759 25 Tests Each
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Product Code. 15863759 Supplier BD Biosciences Supplier No. 564624

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Description

Rat Monoclonal Antibody

The RF8B2 monoclonal antibody specifically binds to the human CXC chemokine receptor, CXCR5. CXCR5 (also known as CD185, BLR-1 NLR and MDR15), a seven transmembrane, G-protein-coupled receptor, is the specific receptor for CXC chemokine, CXCL13/BLC/BCA-1. In peripheral blood, CXCR5 expression is restricted to B lymphocytes and a small subset of CD4+ and CD8+ lymphocytes. The restricted expression pattern of CXCR5 on B cells and follicular T helper cells (Tfh) suggests that this receptor functions as a regulator of B and T cell migration. Stimulation of T cells with anti-CD3 monoclonal antibody leads to the down-regulation of CXCR5.

The antibody was conjugated to BD Horizon BB515 which was developed exclusively by BD Biosciences. With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (eg, 530/30-nm filter). This dye provides a much brighter alternative to FITC with less spillover into the PE detector.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CXCR5
Applications Flow Cytometry
Classification Monoclonal
Clone RF8B2
Conjugate Brilliant Blue 515 (BB515)
Description CD185; Chemokine C-X-C motif receptor 5; BLR1; MDR-15
Formulation Aqueous buffered solution containing ≤0.09% sodium azide
Host Species Rat
Immunogen Human CXCR5
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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For Research Use Only.

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