CPEB Polyclonal Antibody, Invitrogen™

CPEB Antibody, PA1-1100, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: IHC, Immunofluorescence, IHC (P), Western Blot.

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-1100

CPEB

UNSPSC: 12352203

Code: LE

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11545922

Quantity Price
1 £ 331.0 / 100µg
EU Stock 1
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Description and Specification

Specification

Antigen CPEB
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Western Blot
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
Formulation 100μg purified antibody (1mg/mL) in PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No. P0C279, P70166, Q9BZB8
Gene Alias Cytoplasmic Polyadenylation Element Binding Protein
Gene Symbols CPEB1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues C H(545) S M E G L R H H S P L M R N Q K N(562) of human CPEB.
Isotype IgG
Quantity 100μg
Species Reactivity Human, Mouse, Rat
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 12877, 293056, 64506

CPEB1 is an RNA binding protein that contains an RNA-recognition motif and a zinc finger-containing region found in a wide range of vertebrates and invertebrates. CPEB1 forms the nucleus of a complex of factors that regulate poly(A) elongation and promotes polyadenylation-induced translation. CPEB1 mediates many diverse biological processes such as germ cell development, cell division and senescence, and synaptic plasticity. Recently, it was discovered that CPEB1 is involved in beta-catenin mRNA translation and cell migration in astrocytes as well as regulating hypoxia-inducible factor (HIF)-1 expression, demonstrating the wide range of processes in which CPEB1 plays a role. At least four isoforms of CPEB1 are known to exist.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues C H(545) S M E G L R H H S P L M R N Q K N(562) of human CPEB.
Formulation: 100μg purified antibody (1mg/mL) in PBS with 1mg/mL BSA and 0.05% sodium azide
Synonyms: Cytoplasmic Polyadenylation Element Binding Protein
Uniprot Accession: P0C279, P70166, Q9BZB8
Entrez GeneID: 12877, 293056, 64506
Gene Symbol: CPEB1
PA1-1100 detects recombinant mouse and rat CPEB (cytoplasmic polyadenylation element binding protein). PA1-1100 has been successfully used in Western blot, ICC/IF and IHC-P procedures. By Western blot, this antibody detects ∽62 and kDa protein representing recombinant mouse CPEB. The PA1-1100 immunogen is a synthetic peptide corresponding to residues C H(545) S M E G L R H H S P L M R N Q K N(562) of human CPEB. This sequence is completely conserved in mouse. The PA1-1100 immunizing peptide (Cat. # PEP-171) is available for use in neutralization and control experiments.
References:
Test: IP, Species: Ms, Reference: CPEB1 promotes differentiation and suppresses EMT in mammary epithelial cells. (May 2014) J. Cell. Sci., Vol: 127, Pt 10, 2326-38, Grudzien-Nogalska E,Reed BC,Rhoads RE; Pubmed ID: 24634508