CPEB Polyclonal Antibody, Invitrogen™
CPEB Antibody, PA1-1100, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: IHC, Immunofluorescence, IHC (P), Western Blot.
Brand: Invitrogen PA11100
Code : LE
Additional Details : Weight : 0.01000kg
DescriptionCPEB1 is an RNA binding protein that contains an RNA-recognition motif and a zinc finger-containing region found in a wide range of vertebrates and invertebrates. CPEB1 forms the nucleus of a complex of factors that regulate poly(A) elongation and promotes polyadenylation-induced translation. CPEB1 mediates many diverse biological processes such as germ cell development, cell division and senescence, and synaptic plasticity. Recently, it was discovered that CPEB1 is involved in beta-catenin mRNA translation and cell migration in astrocytes as well as regulating hypoxia-inducible factor (HIF)-1 expression, demonstrating the wide range of processes in which CPEB1 plays a role. At least four isoforms of CPEB1 are known to exist.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to residues C H(545) S M E G L R H H S P L M R N Q K N(562) of human CPEB.
Formulation: 100μg purified antibody (1mg/mL) in PBS with 1mg/mL BSA and 0.05% sodium azide
Synonyms: Cytoplasmic Polyadenylation Element Binding Protein
Uniprot Accession: P0C279, P70166, Q9BZB8
Entrez GeneID: 12877, 293056, 64506
Gene Symbol: CPEB1
PA1-1100 detects recombinant mouse and rat CPEB (cytoplasmic polyadenylation element binding protein). PA1-1100 has been successfully used in Western blot, ICC/IF and IHC-P procedures. By Western blot, this antibody detects ∽62 and kDa protein representing recombinant mouse CPEB. The PA1-1100 immunogen is a synthetic peptide corresponding to residues C H(545) S M E G L R H H S P L M R N Q K N(562) of human CPEB. This sequence is completely conserved in mouse. The PA1-1100 immunizing peptide (Cat. # PEP-171) is available for use in neutralization and control experiments.
Test: IP, Species: Ms, Reference: CPEB1 promotes differentiation and suppresses EMT in mammary epithelial cells. (May 2014) J. Cell. Sci., Vol: 127, Pt 10, 2326-38, Grudzien-Nogalska E,Reed BC,Rhoads RE; Pubmed ID: 24634508
|P0C279, P70166, Q9BZB8|
|Cytoplasmic Polyadenylation Element Binding Protein|
|Avoid Freeze/Thaw Cycles|
|100μg purified antibody (1mg/mL) in PBS with 1mg/mL BSA and 0.05% sodium azide|
|Synthetic peptide corresponding to residues C H(545) S M E G L R H H S P L M R N Q K N(562) of human CPEB.|
|12877, 293056, 64506|