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Coronin 1A Chicken anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Product Code. 11585852
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Quantity:
100 μL
Unit Size:
100µL
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11585852 100 μL 100µL
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Product Code. 11585852 Supplier Invitrogen Supplier No. PA110007

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Description

Chicken Polyclonal Antibody

Highly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Coronin 1a
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CORO1A
Gene Accession No. P31146, O89053, Q91ZN1
Gene Alias CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
Gene Symbols CORO1A
Host Species Chicken
Immunogen Purified, recombit human coronin 1a.
Purification Method PEG precipitation
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11151, 12721, 155151
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgY
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