anti-Coronin 1a Polyclonal, Thermo Scientific™

Coronin 1a Polyclonal Ab PA1-10007 from Thermo Scientific™ specifically detects Coronin 1a in Hu, Ms and Rt samples, and it is validated for ICC, IF and WB

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-10007

CORONIN 1A

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11585852

Quantity Price
1 £ 317.0 / 100µL
Estimated Shipment date
from Supplier 06-01-2017
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Description and Specification

Specification

Antigen Coronin 1a
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Western Blot
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
Formulation 100μL purified antibody in PBS and 10mM sodium azide
Gene Accession No. O89053, P31146, Q91ZN1
Gene Alias CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
Gene Symbols CORO1A
Host Species Chicken
Immunogen Purified, recombinant human coronin 1a.
Isotype IgY
Quantity 100μL
Species Reactivity Human, Mouse, Rat
Storage Requirements avoiding freeze/thaw cycles.
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 11151, 12721, 155151

Highly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
Host Species: Chicken
Cross Reactivity: Human, Mouse, Rat
Isotype: IgY
Immunogen: Purified, recombinant human coronin 1a.
Formulation: 100μL purified antibody in PBS and 10mM sodium azide
Synonyms: CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
Uniprot Accession: O89053, P31146, Q91ZN1
Entrez GeneID: 11151, 12721, 155151
Gene Symbol: CORO1A
This product detects Coronin 1a in Human, Mouse and Rat samples. This product has been successfully used in Immunocytochemistry, Immunofluorescence and Western Blot procedures. The immunogen is Purified, recombinant human coronin 1a..