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Coronin 1a Polyclonal Antibody, Invitrogen™

Coronin 1a Antibody, PA1-10022, from Invitrogen™. Species Reactivity: Bovine, Chicken, Equine, Human, Mouse, Porcine, Rat; Applications: ICC, IF, IHC, WB.

Brand:  Invitrogen PA110022

UNSPSC : 12352203

Code : LD

Additional Details : Weight : 0.01000kg

Product Code. 11535872

  • £317.00 / 100µL


Estimated Shipment
23-06-2017
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Specifications

Description

Highly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
Host Species: Rabbit
Cross Reactivity: Bovine, Chicken, Equine, Human, Mouse, Porcine, Rat
Isotype: IgG
Immunogen: Full-length recombinant human Coronin 1a
Formulation: 100μL unpurified antibody in whole serum and no preservative
Synonyms: CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
Uniprot Accession: O89053, P31146, Q91ZN1, Q92176
Entrez GeneID: 100064170, 100621483, 11151, 12721, 155151, 282196
Gene Symbol: CORO1A
This product detects Coronin 1a in Bovine, Chicken, Equine, Human, Mouse, Porcine and Rat samples. This product has been successfully used in Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot procedures. The immunogen is Full-length recombinant human Coronin 1a.
References:
Test: ICC, Dilution: 1:500, Species: Rt, Reference: The effect of simvastatin on the proteome of detergent-resistant membrane domains: decreases of specific proteins previously related to cytoskeleton regulation, calcium homeostasis and cell fate. (2010 May) Proteomics, Vol: 10, 10, 1954-65, Ponce J, Brea D, Carrascal M, Guirao V, Degregorio-Rocasolano N, Sobrino T, Castillo J, Dávalos A, Gasull T; Pubmed ID: 20217863
Description & Specifications

Specifications

Coronin 1a
Unlabeled
O89053, P31146, Q91ZN1, Q92176
CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
Rabbit
IgG
avoiding freeze/thaw cycles.
Polyclonal
Rat
Western Blot
100μL unpurified antibody in whole serum and no preservative
Serum
CORO1A
Full-length recombinant human Coronin 1a
100μL
Primary
100064170, 100621483, 11151, 12721, 155151, 282196