CDK6 Mouse anti-Human, Clone: 75B9, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen LFMA0155

Product Code. 10319899

Description

A suggested positive control for this product is HepG2 cells.

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Specifications

• Antigen: Cdk6
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Accession No.: Q00534
• Gene Symbols: CDK6
• Immunogen: Recombit human protein purified from E.coli
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: 75B9
• Gene: CDK6
• Gene Alias: MGC59692, PLSTIRE
• Host Species: Mouse
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 1021
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid