FAS Mouse anti-Human, Clone: UT-1, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA119024

Product Code. 11514482

Description

CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.

Specifications

• Antigen: FAS
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Gene: FAS
• Gene Alias: ALPS1A, APO-1, APT1, Apo-1 Fas, CD95, FAS1, FASTM, TNFRSF6
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 355
• Content And Storage: 4° C, do not freeze
• Form: Liquid

• Applications: Flow Cytometry, Functional Assay, Western Blot
• Clone: UT-1
• Conjugate: Unconjugated
• Gene Accession No.: P25445
• Gene Symbols: FAS
• Immunogen: T cell lymphoma cells HUT-78.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgM