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Description
The C2 monoclonal antibody specifically binds to CD71, the transferrin receptor. CD71 is a disulfide-linked homodimer of 95-kDa subunits. CD71 mediates one of the cellular mechanisms for iron uptake, and its expression is regulated according to the cell’s iron requirements. It is expressed at high levels on developing erythroid cells, and it is upregulated after mitogenic activation of B or T lymphocytes. The C2 monoclonal antibody selectivity inhibits some types of T- and B-cell activation by down-regulation of transferrin receptor expression, but it does not block binding of transferrin.
Specifications
| CD71 | |
| Monoclonal | |
| 0.2mg/mL | |
| Transferrin Receptor; TR; TfR; TfR1; Tfrc; Trfr; Mtvr-1 | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgG1 κ |
| Flow Cytometry | |
| C2 | |
| Alexa Fluor 647 | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse cell line | |
| 50 μg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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