CD61 Mouse anti-Human, Unlabeled, Clone: 1, BD

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
15825819	BD Biosciences 611140	50 μg
15835819	BD Biosciences 611141	150 μg

Description

Integrins are heterodimeric transmembrane receptors that mediate cell-cell or cell-matrix adhesion. They contain noncovalently associated α and β subunits that consist of a large extracellular region (the ligand-binding domain), a short transmembrane region, and a cytoplasmic domain of varying length. In mammals, at least 17 α subunits and 8 β subunits have been identified and these proteins can heterodimerize to form at least 22 different receptors. Although there is a high degree of redunancy, each integrin has a specific biological function. For example, the β3 subunit associates with αIIb in platelets where this glycoprotein complex acts as a fibrinogen receptor and mediates platelet aggregation. In endothelial cells (EC), β3 complexes with the αv subunit to form the vitronectin receptor. This receptor mediates endothelial cell adhesion to vitronectin, fibrinogen, von Willebrand factor, thrombospondin, laminin, and fibronectin. In confluent EC cultures, the αvβ3 integrin localizes to focal adhesions at the cell body and cell-cell borders. Thus, continued study of individual integrin subunits will provide insights to mechanisms of cell adhesion and signaling.

Host Species: Mouse
Clone: 1
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Integrin β3 aa. 592-712
Formula Weight [Chemical]: 104kDa

Immunofluorescence, Western Blotting

Specifications

• Antigen: CD61
• Concentration: 250μg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Isotype: IgG1
• Purification Method: Affinity Purified
• Description: Integrin β3 chain

• Clone: 1
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Human
• Immunogen: Human Integrin β3 aa. 592-712
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.