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Description
The HM48-1 monoclonal antibody specifically binds to CD48 (previously known as BCM1 in mice, Blast-1 in human, and OX-45 in the rat), a GPI-anchored member of the Ig superfamily. It is widely distributed on leukocytes, but not on non-hematopoietic cells, and its ligands include CD2 (LFA-2) and CD244 (2B4 antigen). The HM48-1 mAb blocks binding of soluble CD2 to CD48-bearing cells, blocks the interaction of CD2 and CD244, inhibits spleen cell proliferative responses to mitogens, augments the proliferative response of spleen cells when cross-linked with anti-CD3e mAbs, and inhibits priming of CTL in vitro. In vivo administration of HM48-1 antibody can prolong survival of cardiac allografts, an effect which is greatly enhanced by the addition of anti-CD2 mAb 12-15. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leukocytes.
Specifications
| CD48 | |
| Monoclonal | |
| 0.2mg/mL | |
| BLAST; BLAST-1; BCM1; HM48-1; MEM-102; Sgp-60; SLAMF2 | |
| Hamster | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| HM48-1 | |
| PE-Cyanine7 | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse T lymphoma MBL-2 | |
| 50 μg | |
| Immunology | |
| Mouse | |
| IgG1 |
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