CD45/PTPRC Alexa Fluor 647 Monoclonal Antibody, Clone: MEM-28, Invitrogen™
CD45/PTPRC Antibody, Alexa Fluor 647 conjugate (MEM-28), MA5-18142, from Invitrogen™. Species Reactivity: Human; Applications: Flow Cytometry.
Brand: Invitrogen MA518142
Code : NEW
Additional Details : Weight : 0.01000kg
DescriptionCD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Host Species: Mouse
Cross Reactivity: Human
Immunogen: Human thymocytes and T lymphocytes
Formulation: 100 tests purified antibody in PBS with 0.2% BSA and 15mM sodium azide
Synonyms: B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide, receptor-type tyrosine-protein phosphatase C
Uniprot Accession: P08575
Entrez GeneID: 5788
Gene Symbol: PTPRC
This antibody reacts with all alternative forms of human CD45 antigen, and will not cross-react with equine.
|100 tests purified antibody in PBS with 0.2% BSA and 15mM sodium azide|
|Human thymocytes and T lymphocytes|
|Alexa Fluor™ 647|
|B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide, receptor-type tyrosine-protein phosphatase C|
|DO NOT FREEZE!|