anti-CD45/PTPRC Clone: MEM-28

CD45/PTPRC Monoclonal antibody MA5-18141 from Thermo Scientific™ specifically detects CD45/PTPRC in Human samples, and it is validated for Flow Cytometry

Overview
Brand: Invitrogen

Manufacturer Part Number: MA518142

Monoclonal Antibody,CD45/PTPRC,Alexa Fluor 647

UNSPSC: 12352203

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 15397404

Quantity Price
1 £ 254.0 / 100 tests
Estimated Shipment date
from Supplier 19-12-2016
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Description and Specification

Specification

Antigen CD45/PTPRC
Applications Flow Cytometry
Clone MEM-28
Conjugate Alexa Fluor 647
Cross Reactivity Human
Format Purified
Formulation 100 tests purified antibody in PBS with 0.2% BSA and 15mM sodium azide
Gene Accession No. P08575
Gene Alias B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide, receptor-type tyrosine-protein phosphatase C
Gene Symbols PTPRC
Host Species Mouse
Immunogen Human thymocytes and T lymphocytes
Isotype IgG1
Quantity 100 TS
Species Reactivity Human
Storage Requirements DO NOT FREEZE!
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 5788

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Host Species: Mouse
Cross Reactivity: Human
Isotype: IgG1
Clone: MEM-28
Immunogen: Human thymocytes and T lymphocytes
Formulation: 100 tests purified antibody in PBS with 0.2% BSA and 15mM sodium azide
Synonyms: B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide, receptor-type tyrosine-protein phosphatase C
Uniprot Accession: P08575
Entrez GeneID: 5788
Gene Symbol: PTPRC
This antibody reacts with all alternative forms of human CD45 antigen, and will not cross-react with equine.