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CD3e Mouse anti-Human, Non-human primate, PerCP, Clone: UCHT1, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA110181

Code : LD

Additional Details : Weight : 0.01000kg

Product Code. 12352203

  • £336.00 / Pack of 100
Estimated Shipment: 16-06-2022
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Description

Description

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Specifications

Specifications

CD3e
Monoclonal
PerCP
CD3E
FLJ18683; T3E; TCRE; CD3-epsilon; CD3e antigen; epsilon polypeptide TiT3 complex; T-cell antigen receptor complex; epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; HCD3
Mouse
Purified
RUO
916
Antibody
IgG1
Flow Cytometry
UCHT1
PBS with 0.2% BSA and 15mM sodium azide
P07766
CD3E
human thymocytes followed by Sezary T cells
100 Tests
Primary
Human, Non-human Primate
Liquid
Videos
SDS
Documents
Certificates
Special Offers

Special Offers