CD3 Rat anti-Mouse, NA/LE, Unlabeled, Clone: 17A2, BD

Rat Monoclonal Antibody

Brand:  BD Biosciences 562163

Product Code. 15801699

Description

The 17A2 monoclonal antibody specifically binds to the T-cell receptor-associated CD3 complex that is expressed on many thymocytes and mature T lymphocytes. Plate-bound 17A2 antibody has been reported to induce IL-2 production by cultured T cells in the absence of accessory cells. The binding of the 17A2 antibody to T cells can be blocked by the anti-CD3e mAb 145-2C11. This suggests that the 17A2 antibody recognizes an epitope of the CD3 epsilon chain. In vivo treatment with 17A2 antibody has been reported to partially deplete T lymphocytes and temporarily down-modulates CD3 expression on T cells.

Specifications

• Antigen: CD3
• Classification: Monoclonal
• Concentration: 1.0mg/mL
• Description: CD3; CD3 epsilon; Cd3e; CD3ε; T3e
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Isotype: IgG2b κ

• Applications: Flow Cytometry
• Clone: 17A2
• Conjugate: Unconjugated
• Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
• Immunogen: Alphadelta TCR-positive T-T hybridoma D1
• Quantity: 0.5 mg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C