CD267 Rat anti-Mouse, Alexa Fluor 647, Clone: 8F10, BD

Rat Monoclonal Antibody

Brand:  BD Biosciences 558453

Product Code. 15859398

Description

Antibody 8F10 reacts with CD267 (TACI) a type III transmembrane protein receptor that binds to the ligands BAFF (BLyS), and APRIL. BAFF overproduction is associated with lupus erythematosus and Sjφgren's disease, two systemic autoimmune diseases. CD267 is expressed most notably on maturing subsets of splenic B cells such as transition type 2 (T2) and marginal zone (MZ) B cells and also in activated T-cells. In CD267 deficient mice, B cell numbers are increased and mice develop autoimmune disorders suggesting that CD267 plays a role in B cell regulation .

Specifications

• Antigen: CD267
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: TACI
• Host Species: Rat
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Mouse
• Isotype: IgG2a κ

• Applications: Flow Cytometry
• Clone: 8F10
• Conjugate: Alexa Fluor 647
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Rat RBL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.