CD195 Mouse anti-Human, APC-Cy7, Clone: 2D7/CCR5, BD

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
15870589	BD Biosciences 560913	25 Tests
15849038	BD Biosciences 557755	100 Tests

Description

Reacts with the chemokine receptor, CCR5, a seven transmembrane-spanning G protein-associated molecule. CCR5 belongs to the β chemokine receptor family. It is expressed on a subset of T lymphocytes (CD3+, CD45RO+, CD95+). CCR5 regulates lymphocyte chemotaxis activation and transendothelial migration during inflammation. It signals a response to at least three chemokines: RANTES and macrophage inflammatory protein-1 (MIP-1) α and β. Additionally, CCR5 has been found to be a co-receptor for macrophage-tropic HIV-1 on CD4+ cells, a characteristic that is important in viral transmission. Reports indicate that individuals who have partial (heterozygous) or complete (homozygous) deletion of the CCR5 allele, demonstrate resistance to HIV infection. This antibody has been shown to block ligand and gp120 binding. It is also able to neutralize HIV infection. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: 2D7/CCR5
Isotype: IgG2a, κ
Species Reactivity: Human

Flow Cytometry, Functional Assay, Immunofluorescence

Specifications

• Antigen: CD195
• Applications: Flow Cytometry
• Conjugate: APC-Cyanine7
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
• Isotype: IgG2a κ
• Purification Method: Affinity Purified
• Description: CCR5; C-C chemokine receptor type 5; CC-CKR-5; CKR5; CHEMR13

• Clone: 2D7/CCR5
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Immunogen: Human CCR5 Transfected Cell Line
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.