CD152 Mouse anti-Human, APC, Clone: BNI3, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 560938

Product Code. 15820619

Description

Reacts with the “cytolytic T lymphocyte-associated antigen”, CTLA-4. CTLA-4 is transiently expressed on activated CD28+ T cells and binds to CD80 and CD86 present on antigen presenting cells (APC) with high avidity. This interaction appears to deliver a negative regulatory signal to the T cell. There are recent reports that indicate that CTLA-4 is also expressed on B cells when cultured with activated T cells, suggesting a possible role of CTLA-4 in the regulation of B-cell response. Immobilized BNI3.1 enhances T-cell proliferation induced by CD3 and CD28. Recent studies have showed that CD152 can be expressed by regulatory T (Treg) cells. It has been found this antibody can stain the
intracellular CD152 on the Treg cells after fixation and permeabilization of cells.

Host Species: Mouse
Clone: BNI3
Isotype: IgG2a κ
Species Reactivity: Human

Flow Cytometry, Intracellular Staining

Specifications

• Antigen: CD152
• Classification: Monoclonal
• Conjugate: APC
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human CTLA4 Recombinant Protein
• Quantity: 25 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: BNI3
• Description: CTLA-4; AILIM; Cytotoxic T-lymphocyte protein 4
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG2a κ

For Research Use Only.