RON Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA186575

Product Code. 11533781

Description

Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for this product is colon surface epithelium. Rabbit anti Human CD136 antibody detects CD136, a receptor tyrosine kinase also known as Macrophage stimulating 1 receptor (MST1R) and RON (Recepteur d’origine tais).

Macrophage-stimulatin 1 receptor (MST1R/Ron), a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uterus.

Specifications

• Antigen: RON
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: Q04912
• Gene Symbols: MST1R
• Immunogen: Synthetic peptide: internal domain of human CD136, conjugated to KLH
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Gene: MST1R
• Gene Alias: CD136, CDw136, PTK8, RON, MSP receptor, MST1R variant RON30, MST1R variant RON62, PTK8 protein tyrosine kinase 8, RON variant E2E3, c-met-related tyrosine kinase, macrophage-stimulating protein receptor, p185-Ron, soluble RON variant 1, soluble RON variant 2, soluble RON variant 3, soluble R
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4486
• Content And Storage: 4°C or -20°C if preferred
• Form: Liquid