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Description
The ICRF44 monoclonal antibody specifically binds to CD11b, the 165-kDa adhesion glycoprotein that associates with the 95-kDa integrin β2 (CD18) to form the CD11b/CD18 complex, also known as Mac-1 or CR3. CD11b is expressed on activated lymphocytes, monocytes, granulocytes, and a subset of NK cells. CD11b functions in cell-cell and cell-substrate interactions and is a receptor for iC3b, CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). This antibody significantly inhibits polymorphonuclear leukocyte aggregation in response to fMLP.
This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Specifications
| CD11b | |
| Monoclonal | |
| 0.5mg/mL | |
| Mac-1α, integrin αM subunit, CR3 α chain | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C |
| Flow Cytometry | |
| ICRF44 | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Human monocytes | |
| 0.1 mg | |
| Immunology | |
| Human | |
| IgG1 κ |
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Product Title
For Research Use Only.
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