CD100 Monoclonal Antibody (A8), APC, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA516558

Product Code. 15205849

Description

Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4oC in the dark. Once reconstituted, this product has a shelf life of approx. 18 months. For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL.

Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 (also known as semaphorin 4d), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.

Specifications

• Antigen: CD100
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: PBS with 1% BSA, 5% sucrose and 0.09% sodium azide
• Gene Accession No.: Q92854
• Gene Symbols: Sema4d
• Immunogen: Human PHA activated lymphocytes
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human, Non-human Primate
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: A8
• Conjugate: APC
• Gene: Sema4d
• Gene Alias: A8; BB18; C9orf164; CD100; coll-4; GR3; M-Sema G; M-sema-G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; sema J; Sema4d; Semacl2; SEMAJ; semaphorin 4D; semaphorin H; semaphorin-4D; Semaphorin-C-like 2; semaphorin-J; Semcl2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 10507
• Content And Storage: 4° C, store in dark, DO NOT FREEZE!
• Form: Lyophilized