Caspase 10 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA112507

Product Code. 11525992

Description

A suggested positive control for this product is HeLa whole cell lysate.

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.

Specifications

• Antigen: Caspase 10
• Classification: Polyclonal
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q92851
• Gene Symbols: CASP10
• Immunogen: Synthetic peptide corresponding to residues 505-521 of human FLICE2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: CASP10
• Gene Alias: ALPS2, FLICE2, MCH4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 843
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid