CARD11 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA529702

Product Code. 13423947

Description

Recommended positive controls: Raji, K562, NCI-H929, BCL-1. Predicted reactivity: Mouse (96%), Chicken (87%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Specifications

• Antigen: CARD11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CARD11
• Gene Alias: 0610008L17Rik; 2410011D02Rik; bcl10-interacting maguk protein 3; BENTA; BIMP3; Card11; CARD-containing MAGUK protein 1; Carma 1; CARMA1; caspase recruitment domain family member 11; caspase recruitment domain family, member 11; caspase recruitment domain-containing protein 11; IMD11; LOC100363332; MGC133069; PPBL
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108723, 84433
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.02 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8CIS0, Q9BXL7
• Gene Symbols: CARD11
• Immunogen: Recombinant fragment corresponding to a region within amino acids 25 and 275 of Human CARD11
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG