BUB1B Polyclonal Antibody, Invitrogen™
BUB1B Antibody, PA1-12553, from Invitrogen™. Species Reactivity: Mouse; Applications: Immunohistochemistry, Western Blot.
Brand: Invitrogen PA112553
Code : LD
Additional Details : Weight : 0.01000kg
DescriptionCompromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
Host Species: Sheep
Cross Reactivity: Mouse
Immunogen: Recombinant protein corresponding to residues 232-603 of mouse Bub1b.
Formulation: 250μg purified antibody in PBS and 0.08% sodium azide
Synonyms: BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1
Uniprot Accession: Q9Z1S0
Entrez GeneID: 12236
Gene Symbol: BUB1B
A suggested positive control for this product is mitotic NIH-3T3 cells.
|BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1|
|Avoid Freeze/Thaw Cycles|
|250μg purified antibody in PBS and 0.08% sodium azide|
|Recombinant protein corresponding to residues 232-603 of mouse Bub1b.|