BUB1B Polyclonal Antibody, Invitrogen™

BUB1B Antibody, PA1-12551, from Invitrogen™. Species Reactivity: Mouse; Applications: Immunohistochemistry, Western Blot.

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-12551

BUB1B

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11576022

Quantity Price
1 £ 274.0 / 250µg
Estimated Shipment date
from Supplier 17-03-2017
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Description and Specification

Specification

Formulation 250μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Gene Symbols BUB1B
Applications Immunohistochemistry
Applications Western Blot
Gene ID (Entrez) 12236
Antigen BUB1B
Storage Requirements Avoid Freeze/Thaw Cycles
Cross Reactivity Mouse
Immunogen Recombinant protein corresponding to residues 883-1052 of mouse Bub1b.
Isotype IgG
Primary or Secondary Primary
Format Purified
Gene Accession No. Q9Z1S0
Host Species Sheep
Species Reactivity Mouse
Conjugate Unlabeled
Gene Alias BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1
Quantity 250μg
Monoclonal or Polyclonal Polyclonal

Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
Host Species: Sheep
Cross Reactivity: Mouse
Isotype: IgG
Immunogen: Recombinant protein corresponding to residues 883-1052 of mouse Bub1b.
Formulation: 250μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Synonyms: BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1
Uniprot Accession: Q9Z1S0
Entrez GeneID: 12236
Gene Symbol: BUB1B
A suggested positive control for this product is mitotic NIH-3T3 cells.