Invitrogen™ BRD7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA541544

Product Code. 15534872

Description

Peptide sequence: KELAQQVTPG DIVSTYGVRK AMGISIPSPV MENNFVDLTE DTEEPKKTDV Sequence homology: Dog: 86%; Guinea Pig: 93%; Horse: 79%; Human: 100%; Rabbit: 79%; Rat: 86%.

BRD7 acts both as coactivator and as corepressor. For example, it activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. In addition, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters, inhibiting cell cycle progression from G1 to S phase.

Specifications

• Antigen: BRD7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BRD7
• Gene Alias: 75 kDa bromodomain protein; BP75; BRD7; bromodomain containing 7; bromodomain protein 75 kDa; bromodomain-containing 7; bromodomain-containing 7-like protein; bromodomain-containing protein 7; CELTIX1; NAG4; protein CELTIX-1; protein tyrosine phosphatase, non-receptor type 13 interacting protein; Ptpn13ip
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29117
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9NPI1
• Gene Symbols: BRD7
• Immunogen: Synthetic peptide directed towards the C-terminal of human BRD7 (aa 594-643).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG