BNIP3L Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA112514

Product Code. 11585992

Description

A suggested positive control for this product is K562 cell lysate.

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3a, and Nix (for Nip3-like protein X Bnip3L/Bnip3a/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria.

Specifications

• Antigen: BNIP3L
• Classification: Polyclonal
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O60238
• Gene Symbols: BNIP3L
• Immunogen: Synthetic peptide corresponding to residues 77-92 of human Bnip3L.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: BNIP3L
• Gene Alias: BNIP3a, NIX
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 665
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid