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  6. BM28 Mouse, Unlabeled, Clone: 46, BD

BM28 Mouse, Unlabeled, Clone: 46, BD

Product Code. 15815599
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Quantity:
150 μg
50 μg
Unit Size:
1 set
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15815599 50 μg 1 set
15825599 150 μg 1 set
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Product Code. 15815599 Supplier BD Biosciences Supplier No. 610700

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Description

Mouse Monoclonal Antibody

BM28 is a phosphoprotein that migrates at 125kDa in SDS PAGE with a hyperphosphorylated form migrating as a slightly slower band. The ratio of the phosphorylation states alters with the phases of cell cycle - in M, the “fast” phosphorylated BM28 is the major form found, while in G1 phase, the “slow”, hyperphosphorylated BM28 predominates. The cellular localization of BM28 is also cell cycle dependent. In G1, most of the BM28 is chromatin bound, whereas, by M phase, the BM28 is still nuclear, but not associated with the DNA. BM28 is necessary for both entry into S phase and cell division as determined by microinjection inhibition experiments. Microinjection of a BM28 antibody into synchronised cells in G1 phase inhibits DNA replication. When injected during S phase or later, no effect on DNA replication is seen, but cell division is inhibited.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen BM28
Applications Western Blot
Classification Monoclonal
Clone 46
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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