Invitrogen™ beta Dystroglycan Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA534908

Product Code. 15358971

Description

Recommended positive controls: H1299, MCF-7. Predicted reactivity: Mouse (89%), Rat (87%), Dog (89%), Cat (94%), Rabbit (89%), Rhesus Monkey (97%), Bovine (91%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.

Specifications

• Antigen: beta Dystroglycan
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DAG1
• Gene Alias: 156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; D9Wsu13e; DAG; DAG1; Dag-1; DG; Dp427; Dp71; dystroglycan; dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1; MDDGA9; MDDGC7; MDDGC9
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13138, 1605
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.6 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q14118, Q62165
• Gene Symbols: DAG1
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human DAG1/beta Dystroglycan. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG