Beclin-1 Polyclonal Antibody, Invitrogen™
Beclin-1 Antibody, PA1-16857, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: ICC, IF, IHC, IHC (Paraffin), IP, WB.
Brand: Invitrogen PA116857
Code : LD
Additional Details : Weight : 0.01000kg
DescriptionBeclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biologic processes in which autophagy is important such as cell differentiation and nutritional stress responses.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide to human Beclin 1, containing residues within 1-100.
Formulation: 100μL purified antibody (1mg/mL) in PBS and 0.02% sodium azide; pH 7.4
Synonyms: CTIP-1 COUP-TF interacting protein 1
Uniprot Accession: O88597, Q14457, Q91XJ1
Entrez GeneID: 114558, 56208, 8678
Gene Symbol: BECN1
The target sequence has 88% sequence homology with rat. Suggested positive control: antigen standard for BECN1 (transient overexpression lysate).
|O88597, Q14457, Q91XJ1|
|CTIP-1 COUP-TF interacting protein 1|
|avoiding freeze/thaw cycles.|
|100μL purified antibody (1mg/mL) in PBS and 0.02% sodium azide; pH 7.4|
|Synthetic peptide to human Beclin 1, containing residues within 1-100.|
|114558, 56208, 8678|