Beclin-1 Polyclonal Antibody, Invitrogen™

Beclin-1 Antibody, PA1-16857, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: ICC, IF, IHC, IHC (Paraffin), IP, WB.

Overview
Brand: Invitrogen

Manufacturer Part Number: PA1-16857

BECLIN-1

UNSPSC: 12352203

Code: LD

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 11565403

Quantity Price
1 £ 331.0 / 100µL
Estimated Shipment date
from Supplier 05-01-2017
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Description and Specification

Specification

Antigen Beclin-1
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blot
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
Formulation 100μL purified antibody (1mg/mL) in PBS and 0.02% sodium azide; pH 7.4
Gene Accession No. O88597, Q14457, Q91XJ1
Gene Alias CTIP-1 COUP-TF interacting protein 1
Gene Symbols BECN1
Host Species Rabbit
Immunogen Synthetic peptide to human Beclin 1, containing residues within 1-100.
Isotype IgG
Quantity 100μL
Species Reactivity Human, Mouse, Rat
Storage Requirements avoiding freeze/thaw cycles.
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 114558, 56208, 8678

Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biologic processes in which autophagy is important such as cell differentiation and nutritional stress responses.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Isotype: IgG
Immunogen: Synthetic peptide to human Beclin 1, containing residues within 1-100.
Formulation: 100μL purified antibody (1mg/mL) in PBS and 0.02% sodium azide; pH 7.4
Synonyms: CTIP-1 COUP-TF interacting protein 1
Uniprot Accession: O88597, Q14457, Q91XJ1
Entrez GeneID: 114558, 56208, 8678
Gene Symbol: BECN1
The target sequence has 88% sequence homology with rat. Suggested positive control: antigen standard for BECN1 (transient overexpression lysate).