Bcl-X Mouse, Unlabeled, Clone: 4, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 610209

Product Code. 15815339

Description

Bcl-x is related to the Bcl-2 protein and can function independently of Bcl-2 in regulating apoptosis (programmed cell death). The bcl-x transcript is found in a number of tissues, with the highest levels in the lymphoid and central nervous systems. Two distinct cDNA species, bcl-xL and bcl-xS, have been observed and appear to arise from alternate 5′ splice sites located within the first coding exon of the bcl-x gene. Bcl-xL is composed of 233 amino acids and is similar in size and structure to Bcl-2. Bcl-xS lacks 63 amino acids corresponding to the region of Bcl-xL with the highest degree of homology to Bcl-2. Like Bcl-2, Bcl-xL has been reported to inhibit cell death upon growth factor withdrawal in an IL-3-dependent cell line. However, Bcl-xS inhibits the ability of Bcl-2 to enhance cell survival in the absence of growth factors.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: Bcl-X
• Classification: Monoclonal
• Concentration: 250μg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Chicken, Mouse, Rat
• Isotype: IgG2b

• Applications: Western Blot
• Clone: 4
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.