anti-ATG7 Polyclonal, Thermo Scientific™

ATG7 Polyclonal Ab PA5-35203 from Thermo Scientific™ specifically detects ATG7 in Hu and Ms samples, and it is validated for ICC, IF, IHC(P) and WB

Overview
Brand: Invitrogen

Manufacturer Part Number: PA535204

Polyclonal Antibody, ATG7, Host Rabbit

UNSPSC: 12352203

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg



Product Code. 15377614

Quantity Price
1 £ 325.0 / 400µL
Estimated Shipment date
from Supplier 16-12-2016
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Description and Specification

Specification

Antigen ATG7
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Western Blot
Conjugate Unlabeled
Cross Reactivity Human
Format Purified
Formulation 400μL purified antibody (Lot-specific) in PBS and 0.09% sodium azide
Gene Accession No. O95352
Gene Alias ATG7; APG7L; Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; Ubiquitin-activating enzyme E1-like protein
Gene Symbols ATG7
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human ATG7
Isotype IgG
Quantity 400μL
Species Reactivity Human
Storage Requirements Store at 2-8°C for up to 6 months. For long term storage store at -20°C
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 10533

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: KLH conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human ATG7
Formulation: 400μL purified antibody (Lot-specific) in PBS and 0.09% sodium azide
Synonyms: ATG7; APG7L; Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; Ubiquitin-activating enzyme E1-like protein
Uniprot Accession: O95352
Entrez GeneID: 10533
Gene Symbol: ATG7
This antibody is predicted to react with chicken, mouse and rat based on sequence homology.