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ATG7 Polyclonal Antibody, Invitrogen™

ATG7 Antibody, PA5-35204, from Invitrogen™. Species Reactivity: Human; Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot.

Brand:  Invitrogen PA535204

UNSPSC : 12352203

Code : NEW

Additional Details : Weight : 0.01000kg

Product Code. 15377614

  • £325.00 / 400┬ÁL


Estimated Shipment
11-10-2017
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Description

Description

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: KLH conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human ATG7
Formulation: 400μL purified antibody (Lot-specific) in PBS and 0.09% sodium azide
Synonyms: ATG7; APG7L; Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; Ubiquitin-activating enzyme E1-like protein
Uniprot Accession: O95352
Entrez GeneID: 10533
Gene Symbol: ATG7
This antibody is predicted to react with chicken, mouse and rat based on sequence homology.
Specifications

Specifications

ATG7
Unconjugated
O95352
ATG7; APG7L; Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; Ubiquitin-activating enzyme E1-like protein
Rabbit
IgG
Store at 2-8°C for up to 6 months. For long term storage store at -20°C
Polyclonal
Human
Western Blot
400μL purified antibody (Lot-specific) in PBS and 0.09% sodium azide
Purified
ATG7
KLH conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human ATG7
400μL
Primary
10533