ARHGEF17 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA538768

Product Code. 15555681

Description

Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predomit expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.

Specifications

• Antigen: ARHGEF17
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARHGEF17
• Gene Alias: P164RHOGEF, TEM4, p164-RhoGEF, 164 kDa Rho-specific guanine-nucleotide exchange factor, Rho-specific guanine-nucleotide exchange factor 164 kDa, rho guanine nucleotide exchange factor 17, tumor endothelial marker 4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 207212, 9828
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q96PE2, Q80U35
• Gene Symbols: ARHGEF17
• Immunogen: A synthetic peptide derived from the internal region of human ARHGEF17
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG