Arg3.1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA118302

Product Code. 11541972

Description

The immunogenic sequence is homologous with mouse and rat Arg3.1. Reconstitute with 500 μL of distilled water. After reconstitution keep aliquots at -20o for a higher stability, and at 4oC with an appropriate antibacterial agent.

Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory. Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1. In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.

Specifications

• Antigen: Arg3.1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Arc
• Gene Alias: activity regulated cytoskeletal-associated protein; activity regulated cytoskeleton associated protein; activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein; activity-regulated gene 3.1 protein homolog; Arc; arc {ECO:0000312; ARC/ARG3.1; Arc3.1; arg3.1; Arg3.1/ARC; C86064; Growth factor ARC; hArc; KIAA0278; mArc; rg3.1; RGD:62037}
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 11838, 23237, 54323
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen)
• Concentration: 1 mg/mL
• Formulation: antibody with no preservative
• Gene Accession No.: Q63053, Q7LC44, Q9WV31
• Gene Symbols: Arc
• Immunogen: Synthetic peptide corresponding to the C-terminal residues of human Arg3.1.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG